Supporting families and persons affected by VCFS or Deletion 22q11.2
Velo-cardio-facial syndrome (VCFS) or 22q11.2 Deletion Syndrome is a genetic syndrome. It is the result of a submicroscopic deletion on the long arm of Chromosome 22 in the “q11” region- deletion 22q11.
- VCFS affects approx. 1 in 2000 - 3000 persons making it the second most prevalent genetic syndrome after Down syndrome
- VCFS is the most common genetic syndrome associated with cleft palates
- VCFS is the second most common genetic syndrome associated with congenital heart defects
- 99% of the VCFS population will have a learning difficulty or disability
- 30% of the VCFS population will develop a mental illness. (Nearly half (45%) of the general population (non VCFS/22q11.2DS) in Australia will experience a mental disorder at some stage in their lives.)
- VCFS has more than 180 anomalies associated with it
- The name velo cardio facial syndrome comes from the Latin words "velum" meaning palate, "cardio" meaning heart and "facies" having to do with the face.
VCFS is also known as:
- Deletion 22q11.2 Syndrome
- DiGeorge Sequence (DGS)
- Shprintzen Syndrome
- CATCH 22
- Conotruncal anomaly face syndrome
- Cayler cardiofacial syndrome.
When a child's health problems are puzzling......
A missing piece of genetic material on chromosome 22 (deletion 22q11) may be the clue.
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